An individualized approach to sustained inflation duration at birth improves outcomes in newborn preterm lambs

DG Tingay; A Lavizzari; CEE Zonneveld; A Rajapaksa; E Zannin; E Perkins; D Black; M Sourial; RL Dellacá; F Mosca; A Adler; B Grychtol; I Frerichs; PG Davis

Journal article

An individualized approach to sustained inflation duration at birth improves outcomes in newborn preterm lambs

DG Tingay, A Lavizzari, CEE Zonneveld, A Rajapaksa, E Zannin, E Perkins, D Black, M Sourial, RL Dellacá, F Mosca, A Adler, B Grychtol, I Frerichs, PG Davis

American Journal of Physiology Lung Cellular and Molecular Physiology | Published : 2015

DOI: 10.1152/ajplung.00277.2015

Abstract

A sustained first inflation (SI) at birth may aid lung liquid clearance and aeration, but the impact of SI duration relative to the volume-response of the lung is poorly understood. We compared three SI strategies: 1) variable duration defined by attaining volume equilibrium using real-time electrical impedance tomography (EIT; SIplat); 2) 30 s beyond equilibrium (SIlong); 3) short 30-s SI (SI30); and 4) positive pressure ventilation without SI (no-SI) on spatiotemporal aeration and ventilation (EIT), gas exchange, lung mechanics, and regional early markers of injury in preterm lambs. Fifty-nine fetal-instrumented lambs were ventilated for 60 min after applying the allocated first inflation ..

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University of Melbourne Researchers

David Tingay Author

Peter Davis Author

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Funding Acknowledgements

This study is supported by a National Health and Medical Research Council Project Grant 1009287 (Canberra, Australia) and the Victorian Government Operational Infrastructure Support Program. D. G. Tingay is supported by a National Health and Medical Research Council Clinical Career Development Fellowship Grant 1053889. P. G. Davis is supported by a National Health and Medical Research Council Program Grant 606789 and Practitioner Fellowship Grant ID 556600.